Our
Pipeline
We bring 40 years of innovation to the ADC field. The US FDA recently granted accelerated approval to our lead product for the treatment of ovarian cancer and we have a number of novel ADCs in development in our pipeline.
Therapeutic Area
Compound
Preclinical
Phase 1
Phase 2
Phase 3
MARKETED
Ovarian Cancer
SORAYA: Monotherapy in FRα-High Platinum-Resistant Ovarian Cancer (Single-Arm Pivotal Trial)
ELAHERE™ APPROVED NOVEMBER 2022; SEE FULL PRESCRIBING INFORMATION, INCLUDING BOXED WARNINGMIRASOL: Monotherapy in FRα-High Platinum-Resistant Ovarian Cancer (Randomized Confirmatory Trial) POSITIVE TOP-LINE DATA REPORTED MAY 2023
GLORIOSA: Doublet with Mirvetuximab + Bevacizumab Maintenance in FRα-High Platinum-Sensitive Ovarian Cancer (Randomized Trial)
PICCOLO: Monotherapy in FRα-High Platinum-Sensitive Ovarian Cancer (Single-Arm Trial) FULLY ENROLLED
420: Doublet with Mirvetuximab + Carboplatin in FRα-Low, -Medium, and -High Platinum-Sensitive Ovarian Cancer (Single-Arm Trial)
Ovarian
Other Solid Tumors
NSCLC, Gastric, Pancreatic, TNBC, and Other Solid Tumors
Endometrial
NSCLC and TNBC
BPDCN
CADENZA (801): Monotherapy in BPDCN
(Includes Single-Arm Pivotal Cohort in Frontline)
AML
802: Combination with Azacitidine and/or Venetoclax
in AML
ADAM9: a disintegrin and a metalloprotease 9; ADC: antibody-drug conjugate; AML: acute myeloid leukemia; BPDCN: blastic plasmacytoid dendritic cell neoplasm; CD: cluster of differentiation; FRα: folate receptor alpha; NSCLC: non-small cell lung cancer; TNBC: triple-negative breast cancer
For clinical trial information, contact: medicalaffairs@immunogen.com.
ImmunoGen’s investigational products have not been approved by the U.S. Food and Drug Administration or other regulatory authorities. The safety and efficacy of investigational products have not been established.
partnerships
In addition to our own, proprietary pipeline of ADC candidates, we have a number of partnerships and collaborations in place that leverage our technology – and those of our collaborators – to address unmet medical needs. We continually seek innovative partnerships with the goal of advancing science, gaining access to complimentary capabilities, strengthening our financial position, and creating more value for ImmunoGen.
Examples of our partnerships include a strategic cross-licensing agreement with CytomX Therapeutics to develop ProbodyTM drug conjugate (PDC) therapies and a co-development and co-promotion collaboration with MacroGenics to develop a first-in-class ADAM9-targeting ADC.
legacy platform deals
Our technology platform has been the basis for a number of high-value partnerships for the company, including the first-ever ADC approved as a treatment option for HER2-positive breast cancer, which is marketed by Roche, called Kadcyla®.
In addition to Roche, we have ADC technology deals in place with Amgen, Bayer, and Sanofi.
