Our
Pipeline
We bring 40 years of innovation to the ADC field. Our lead program, mirvetuximab soravtansine, is a first-in-class ADC in Phase 3 development for platinum-resistant ovarian cancer and we have a number of ADCs in development in our clinical and early stage pipelines.
Compound
Preclinical Research
Preclinical Development
Phase 1
Phase 2
Phase 3
Mirvetuximab Soravtansine
TARGET: Anti-FRa ADC
SORAYA: Monotherapy in FRa-High Platinum-Resistant Ovarian Cancer (Single-Arm Pivotal Trial)
MIRASOL: Monotherapy in FRa-High Platinum-Resistant Ovarian Cancer (Randomized Confirmatory Trial)
FORWARD II: COMBINATIONS WITH AVASTIN® OR CARBOPLATIN IN RECURRENT OVARIAN CANCER
IMGN632
TARGET: Anti-CD123 ADC
801: Monotherapy in BPDCN (Includes Single-Arm Pivotal Cohort in Frontline)
802: COMBINATIONS WITH VIDAZA® AND/OR VENCLEXTA® IN AML
802: Monotherapy in MRD+ AML
IMGN151
TARGET: Anti-FRa Biparatopic ADC
Ovarian, Endometrial, NSCLC, and TNBC
IMGC936
TARGET: Anti-ADAM9 ADC
NSCLC, Gastric, Pancreatic, TNBC, and Other Solid Tumors
partnerships
In addition to our own, proprietary pipeline of ADC candidates, we have a number of partnerships and collaborations in place that leverage our technology – and those of our collaborators – to address unmet medical needs. We continually seek innovative partnerships with the goal of advancing science, gaining access to complimentary capabilities, strengthening our financial position, and creating more value for ImmunoGen.
Examples of our partnerships include a strategic cross-licensing agreement with CytomX Therapeutics to develop ProbodyTM drug conjugate (PDC) therapies and a co-development and co-promotion collaboration with MacroGenics to develop a first-in-class ADAM9-targeting ADC.
legacy platform deals
Our technology platform has been the basis for a number of high-value partnerships for the company, including the first-ever ADC approved as a treatment option for HER2-positive breast cancer, which is marketed by Roche, called Kadcyla®.
In addition to Roche, we have ADC technology deals in place with Amgen, Bayer, and Sanofi.
